[Post-infectious temporary cold agglutinin disease. A case of delayed formation of antibodies against Mycoplasma pneumoniae].

Following an acute febrile infection of the respiratory tract, a 35-year-old man suffered from livid and painful discoloration of his acral regions even after moderate cold exposure. In his serum, high titers of cold agglutinins with anti-I specificity were present. Cold-related symptoms disappeared within 3 weeks. The clinical features and the finding of anti-I cold agglutinins are compatible with postinfections cold agglutinin disease following an infection with mycoplasma pneumoniae. However, antibodies directed against mycoplasma pneumoniae were only demonstrable after the cold agglutinin-dependent symptoms had disappeared.