Litwin S D
Med Hypotheses. 1982 Sep;9(3):313-23. doi: 10.1016/0306-9877(82)90161-x.
The observation that a number of gene clusters or "supergenes" are critical in the genetic regulation of the immune response was used to introduce the hypothesis that multiple X chromosome genes are similarly organized and that they play some special critical role in the immune response. The evidence discussed included current information on several of the human X-linked immune deficiencies, data from mice and studies suggesting X chromosome genes have "regulatory" functions in non-immune tissues. A set of potentially testable speculations based on the hypothesis were advanced.
一些基因簇或“超级基因”在免疫反应的基因调控中至关重要，这一观察结果被用来提出一个假设，即多个X染色体基因也以类似方式组织，并且它们在免疫反应中发挥着某些特殊的关键作用。所讨论的证据包括有关几种人类X连锁免疫缺陷的当前信息、来自小鼠的数据以及表明X染色体基因在非免疫组织中具有“调节”功能的研究。基于该假设提出了一组具有潜在可测试性的推测。
