与狼疮样综合征相关的补体缺陷的遗传学
Genetics of complement deficiencies associated with lupus-like syndromes.
作者信息
Schur P H
出版信息
Arthritis Rheum. 1978 Jun;21(5 Suppl):S153-60. doi: 10.1002/art.1780210924.
PMID:96843
Abstract
There appears to be an association between deficiencies of a number of complement components, particularly of the second component (C2), and rheumatic diseases, especially lupus. The meaning of this association is not clear, but the linkage of deficiency of C2 with HLA, especially HLA-A10, B18, Dw2, as well as with BfS, suggests a possible linkage to immune response genes.
摘要
许多补体成分缺乏，尤其是第二成分（C2）缺乏，似乎与风湿性疾病，特别是狼疮之间存在关联。这种关联的意义尚不清楚，但C2缺乏与HLA，尤其是HLA - A10、B18、Dw2以及与BfS的连锁，提示可能与免疫反应基因有关。
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