Mullane K M, Moncada S
Prostaglandins. 1982 Aug;24(2):255-66. doi: 10.1016/0090-6980(82)90151-4.
BW755C, a dual inhibitor of the lipoxygenase and cyclo-oxygenase pathways of arachidonic acid metabolism reduces the size of an infarct produced by 60 min of coronary occlusion followed by 5 hours reperfusion in anaesthetised beagles. This effect of BW755C is observed when the drug is given after the period of occlusion, and is independent of any haemodynamic effect. In contrast, indomethacin, which inhibits only the cyclo-oxygenase pathway, did not influence infarct size. It is suggested that the salvage of acutely ischaemic myocardium by BW755C is due to inhibition of lipoxygenase product formation by migrating cells which invade the damaged myocardium to produce an inflammatory response.
BW755C是花生四烯酸代谢的脂氧合酶和环氧化酶途径的双重抑制剂，可减小麻醉的比格犬冠状动脉闭塞60分钟后再灌注5小时所产生的梗死面积。当在闭塞期后给予该药物时可观察到BW755C的这种作用，且该作用与任何血流动力学效应无关。相比之下，仅抑制环氧化酶途径的吲哚美辛对梗死面积没有影响。有人提出，BW755C对急性缺血心肌的挽救作用是由于抑制了迁移至受损心肌以产生炎症反应的细胞所形成的脂氧合酶产物。
