Morin R J, Guo L S, Rorke S J, Davidson W D
J Dial. 1978;2(2):113-29. doi: 10.3109/08860227809079312.
Plasma triglyceride and cholesterol concentrations were elevated in dogs after nephrectomy induced uremia. Plasma triglyceride concentrations remained constant during a 4-hour period of hemodialysis of uremic and non-uremic dogs against an acetate concentration of 39.5 mM (delivering 3 mEq/Kg/hr) plus infusion of 12.5 muCi/Kg/hr of acetate-1-14C, but rose progressively following dialysis. Radioactivities in plasma phospholipids, triglycerides and cholesteryl esters increased during dialysis and continued to rise in the post dialysis period, whereas 14C activity in free fatty acids and free cholesterol increased during dialysis and decreased post-dialysis. Acetate 14-C incorporation into plasma triglycerides was similar in the uremic and non-uremic groups, but incorporation into plasma cholesterol was higher in the uremics. Liver triglyceride concentrations and radioactivities at 12 hours were higher in the uremic dogs. At this time, adipose tissue 14C incorporation was also higher in uremic dogs but no differences were observed in aorta, heart or sciatic nerve incorporation. The results suggest that acetate may contribute to the increased plasma triglyceride concentrations observed following dialysis, and that uremia further accentuates acetate incorporation into plasma cholesterol and liver triglycerides.
肾切除诱导的尿毒症犬血浆甘油三酯和胆固醇浓度升高。对尿毒症犬和非尿毒症犬以39.5 mM的醋酸盐浓度（每小时输送3 mEq/Kg）加每小时输注12.5 μCi/Kg的醋酸盐-1-14C进行4小时血液透析期间，尿毒症犬和非尿毒症犬的血浆甘油三酯浓度保持恒定，但透析后逐渐升高。透析期间血浆磷脂、甘油三酯和胆固醇酯中的放射性增加，透析后阶段继续上升，而游离脂肪酸和游离胆固醇中的14C活性在透析期间增加，透析后降低。尿毒症组和非尿毒症组中醋酸盐14-C掺入血浆甘油三酯的情况相似，但尿毒症组中掺入血浆胆固醇的情况更高。尿毒症犬12小时时肝脏甘油三酯浓度和放射性更高。此时，尿毒症犬脂肪组织中的14C掺入也更高，但在主动脉、心脏或坐骨神经掺入方面未观察到差异。结果表明，醋酸盐可能导致透析后观察到的血浆甘油三酯浓度升高，并且尿毒症进一步加剧了醋酸盐掺入血浆胆固醇和肝脏甘油三酯。
