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醋酸盐与碳酸氢盐血液透析对尿毒症患者血浆脂质和脂蛋白水平的影响。

Effect of hemodialysis with acetate vs bicarbonate on plasma lipid and lipoprotein levels in uremic patients.

作者信息

Morin R J, Srikantaiah M V, Woodley Z, Davidson W D

出版信息

J Dial. 1980;4(1):9-20. doi: 10.3109/08860228009065323.

DOI:10.3109/08860228009065323
PMID:7410679
Abstract

A group of 18 stable hemodialysis patients were dialyzed alternately for 4 week periods against acetate or bicarbonate solutions. Total plasma cholesterol and triglyceride concentrations and the content of these lipids in the VLDL, LDL, and HDL lipoprotein fractions were not significantly different when these dialysis periods were compared. When patients were subgrouped according to whether they were normo or hypertriglyceridemic or whether they had an adequate or deficient lipolytic response to heparin infusion, there were also no differences apparent between the acetate vs. bicarbonate dialysis periods. The data indicates, therefore, that acetate is probably not a contributory factor to the hypertriglyceridemias observed in some chronic hemodialysis patients.

摘要

一组18名稳定的血液透析患者分别使用醋酸盐或碳酸氢盐溶液交替进行为期4周的透析。当比较这些透析阶段时,总血浆胆固醇和甘油三酯浓度以及这些脂质在极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)脂蛋白组分中的含量没有显著差异。当根据患者是正常甘油三酯血症还是高甘油三酯血症,或者他们对肝素输注的脂解反应是充足还是不足进行亚组划分时,醋酸盐与碳酸氢盐透析阶段之间也没有明显差异。因此,数据表明,醋酸盐可能不是一些慢性血液透析患者中观察到的高甘油三酯血症的促成因素。

相似文献

1
Effect of hemodialysis with acetate vs bicarbonate on plasma lipid and lipoprotein levels in uremic patients.醋酸盐与碳酸氢盐血液透析对尿毒症患者血浆脂质和脂蛋白水平的影响。
J Dial. 1980;4(1):9-20. doi: 10.3109/08860228009065323.
2
Effects of chronic uremia, hemodialysis, and renal transplantation on plasma lipids and lipoproteins in man.慢性尿毒症、血液透析及肾移植对人体血浆脂质和脂蛋白的影响。
J Lab Clin Med. 1976 Jan;87(1):38-48.
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Effects of acetate or bicarbonate dialysis solutions on serum HDL and HDL subfractions of patients undergoing haemodialysis.醋酸盐或碳酸氢盐透析液对血液透析患者血清高密度脂蛋白及其亚组分的影响。
Curr Med Res Opin. 1999;15(4):310-5. doi: 10.1185/03007999909116502.
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Lower serum high-density lipoprotein-cholesterol concentration in patients undergoing maintenance hemodialysis with acetate than with bicarbonate.接受醋酸盐维持性血液透析的患者血清高密度脂蛋白胆固醇浓度低于接受碳酸氢盐维持性血液透析的患者。
Am J Kidney Dis. 1995 Apr;25(4):584-8. doi: 10.1016/0272-6386(95)90127-2.
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Effect of dialysis on lipid metabolism in chronic renal failure - acetate versus bicarbonate.
Int J Artif Organs. 1983 Jul;6(4):187-90.
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Improved lipid profiles with bicarbonate dialysis.碳酸氢盐透析可改善血脂谱。
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[Comparative effects of hemodialysis using acetate and bicarbonate baths on lipid metabolism].[使用醋酸盐和碳酸氢盐浴进行血液透析对脂质代谢的比较效果]
Nephrologie. 1983;4(4-5):228.
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Lipid metabolism in non-uremic and uremic dogs during and after hemodialysis with acetate.醋酸盐血液透析期间及之后非尿毒症和尿毒症犬的脂质代谢
J Dial. 1978;2(2):113-29. doi: 10.3109/08860227809079312.
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Lipoprotein metabolism in patients with chronic uremia. Effect of hemodialysis on serum lipoproteins and postheparin plasma triglyceride lipases.慢性尿毒症患者的脂蛋白代谢。血液透析对血清脂蛋白和肝素后血浆甘油三酯脂肪酶的影响。
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Atherogenic lipoprotein changes in the absence of hyperlipidemia in patients with chronic renal failure treated by hemodialysis.接受血液透析治疗的慢性肾衰竭患者在无高脂血症情况下的致动脉粥样硬化脂蛋白变化。
Atherosclerosis. 1997 Jun;131(2):229-36. doi: 10.1016/s0021-9150(97)00054-3.

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