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Demonstration of gene dosage effects on antigens in the Duffy, Ss, and Rh systems using an enzyme-linked immunosorbent assay.

作者信息

Caren L D, Bellavance R, Grumet F C

出版信息

Transfusion. 1982 Nov-Dec;22(6):475-8. doi: 10.1046/j.1537-2995.1982.22683068606.x.

DOI:10.1046/j.1537-2995.1982.22683068606.x
PMID:6815840
Abstract

Using a recently developed enzyme-linked immunosorbent assay, gene dosage effects were demonstrated for the Duffy, Ss, and Rh red blood cell antigen systems. We report a comparison by an antibody-binding assay of the relative amounts of Fya and Fyb antigens on FyaFya, FyaFyb, FybFyb, FyaFyx, and FyxFyx erthrocytes, and of s antigen on cells homozygous and heterozygous for s. The immunosorbent assay also was used to study Rh antigens, and data which had been obtained using radiolabelled antibodies were confirmed.

摘要

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Demonstration of gene dosage effects on antigens in the Duffy, Ss, and Rh systems using an enzyme-linked immunosorbent assay.
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2
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