Hahn von Dorsche H, Schwesinger G, Fischer U, Nowak W, Wolter S
Acta Histochem. 1982;71(1):119-32.
Histochemical and electronmicroscopic findings on chronically and selectively denervated pancreata of 8 dogs are described. Most nerve fibers showed marked degeneration and perineuritis, and there was an inflammation of intrapancreatic ganglia. There was no change in the number of islets or in the A-B-cell ratio. Insulitis frequently has been observed. Both immunohistochemically demonstrable insulin in the B-cells, and glucagon in the A-cells were reduced in relation to that in non-denervated controls. There were single A- and B-cells within the acini in an apparently normal frequency. Many pancreata showed a chronic infiltration and fibroblastic inflammation within the acini but their extent varied considerably between the animals. Intrapancreatic blood vessels were generally dilated, hyperemic, and perivascular fibrosis was seen in some cases; the vessels contained many leucocytes. Acinar cells were often subjected to vacuolic degeneration. Another part of them showed, however, increased appearance of ergastoplasm, mitochondria, and of Golgi apparatus as a sign of increased functional stimulation. There were fibrosis and mononuclear infiltration in the medium-sized and large pancreatic ducts.
描述了对8只犬慢性选择性去神经支配胰腺的组织化学和电子显微镜检查结果。大多数神经纤维显示出明显的变性和神经炎，胰腺内神经节存在炎症。胰岛数量或A - B细胞比例无变化。常观察到胰岛炎。与未去神经支配的对照相比，B细胞中免疫组化可检测到的胰岛素以及A细胞中的胰高血糖素均减少。腺泡内可见单个A细胞和B细胞，频率明显正常。许多胰腺在腺泡内表现出慢性浸润和成纤维细胞性炎症，但其程度在不同动物之间差异很大。胰腺内血管普遍扩张、充血，部分病例可见血管周围纤维化；血管内有许多白细胞。腺泡细胞常发生空泡变性。然而，其中另一部分显示粗面内质网、线粒体和高尔基体的出现增加，表明功能刺激增强。中、大胰管存在纤维化和单核细胞浸润。
