Ingvarsson L, Lundgren K
Acta Otolaryngol. 1982 Sep-Oct;94(3-4):283-7. doi: 10.3109/00016488209128915.
Two hundred and ninety-seven children, aged 6 months to 7 years, with AOM were treated with penicillin V. One hundred and forty-eight children were given 25 or 50 mg/kg body weight twice a day for 5 days, and 149 children 25 mg/kg body weight twice a day for 10 days. No differences were found in the rate of healing between the 5- and 10-day groups. The larger penicillin dose, which was given to half the 5-day group, did not lead to improved healing. Treatment with penicillin for 5 days instead of 10 does not mean any increased risk of complications such as SOM, relapses, or therapeutic failure. Nor does the risk of a recurrence of otitis increase either. The investigation showed that the treatment of AOM with penicillin for 10 days, which is the rule in Sweden, can be reduced to 5 days with maintained satisfactory healing and without risk of increasing the number of complications.
297名年龄在6个月至7岁之间的急性中耳炎患儿接受了青霉素V治疗。148名儿童每天两次给予25或50毫克/千克体重，持续5天，149名儿童每天两次给予25毫克/千克体重，持续10天。5天组和10天组之间的愈合率没有差异。给予5天组一半儿童的较大青霉素剂量并未导致愈合改善。用青霉素治疗5天而非10天并不意味着诸如分泌性中耳炎、复发或治疗失败等并发症风险增加。中耳炎复发的风险也没有增加。调查表明，在瑞典通常采用的用青霉素治疗急性中耳炎10天的方案可减至5天，愈合情况良好，且不会增加并发症的数量。
