Pihlstedt P
Acta Med Scand. 1982;212(3):187-90. doi: 10.1111/j.0954-6820.1982.tb03197.x.
Three cases of advanced macroglobulinemia (two with severe cryoglobulinemia) have been treated for 6, 4 and 3 years, respectively, with regular plasma exchange and, during the last two years, also with short courses of cytostatics. The plasma exchange regimen has given the patients a marked relief from hyperviscosity symptoms and may have contributed to the improved peripheral blood values and lowered P-IgM levels. Addition of cytostatics, however, was necessary to obtain a lasting remission.
三例晚期巨球蛋白血症患者（两例伴有严重冷球蛋白血症）分别接受了6年、4年和3年的治疗，采用定期血浆置换，在过去两年中还结合了短期的细胞抑制剂治疗。血浆置换方案使患者的高黏滞症状得到显著缓解，可能有助于改善外周血指标并降低P-IgM水平。然而，添加细胞抑制剂对于获得持久缓解是必要的。
