Beck J R, Quinn B M, Meier F A, Rawnsley H M
Transfusion. 1982 Jan-Feb;22(1):51-3. doi: 10.1046/j.1537-2995.1982.22182154217.x.
Clinical and laboratory indices of hyperviscosity were studied in three patients presenting with this complication of paraproteinemia. Serum viscosity correctly predicted the presence of clinical hyperviscosity syndrome in patients with stable hemoglobin and albumin concentrations. Serum viscosity also correlated with total protein and paraprotein levels. A simple exponential model proved not only to describe the kinetics of blood viscosity during plasma exchange but also to predict protein concentration at symptomatic recovery. Construction of such a protein-viscosity curve helps manage by plasma exchange patients with paraproteinemia who develop hyperviscosity syndrome.
对三名出现副蛋白血症这一并发症的患者进行了高黏滞血症的临床和实验室指标研究。在血红蛋白和白蛋白浓度稳定的患者中，血清黏度能正确预测临床高黏滞血症综合征的存在。血清黏度也与总蛋白和副蛋白水平相关。一个简单的指数模型不仅被证明可以描述血浆置换过程中血液黏度的动力学，还能预测症状缓解时的蛋白质浓度。构建这样的蛋白质-黏度曲线有助于通过血浆置换来管理发生高黏滞血症综合征的副蛋白血症患者。
