黄曲霉毒素B1急性处理后雄性大鼠的类固醇生成和精子发生潜能。

Steroidogenic and spermatogenic potentials of the male rat after acute treatment with aflatoxin B1.

作者信息

Egbunike G N

出版信息

Andrologia. 1982 Sep-Oct;14(5):440-6. doi: 10.1111/j.1439-0272.1982.tb02291.x.

DOI:10.1111/j.1439-0272.1982.tb02291.x

Abstract

150 microgram of aflatoxin B1 were injected i.p]. to male rats on three occasions at intervals 48 h. Sperm production and plasma and testicular testosterone concentrations were determined in rats killed 24 h after the last dose of aflatoxin with or without stimulation with human chorionic gonadotropin (HCG). Neither sperm production nor testosterone secreting capacity was significantly depressed by the acute aflatoxin treatment. The Leydig cell function was however impaired as indicated by the extremely reduced responsiveness of the Leydig cells of the aflatoxin-pretreated rats to HCG stimulation. It may be concluded that the disruption of spermatogenesis by chronic aflatoxin treatment is preceded and caused by the impairment of the Leydig cell function and the resultant drop in testosterone in the testis.

摘要

给雄性大鼠腹腔注射150微克黄曲霉毒素B1，分三次注射，间隔48小时。在最后一剂黄曲霉毒素注射后24小时处死大鼠，测定有无人类绒毛膜促性腺激素（HCG）刺激情况下的精子生成量、血浆和睾丸睾酮浓度。急性黄曲霉毒素处理并未显著降低精子生成量或睾酮分泌能力。然而，如黄曲霉毒素预处理大鼠的睾丸间质细胞对HCG刺激的反应性极度降低所示，睾丸间质细胞功能受损。可以得出结论，慢性黄曲霉毒素处理导致的精子发生破坏之前，是睾丸间质细胞功能受损以及由此导致的睾丸睾酮水平下降。