Finley J L, Clark R A, Colvin R B, Blackman R, Noe J, Rosen S
Arch Dermatol. 1982 Dec;118(12):971-5.
Specific antibodies directed against three important components of the vessel wall (collagenous basement membrane protein-type IV collagen, fibronectin, and factor VIII) were used to study and compare the distribution of these proteins in normal skin and port wine stains. Collagenous basement membrane protein was localized to the basement membrane and basal lamina zones of blood vessels, appendages, arrector pili muscles, endoneurium and perineurium, and the dermoepidermal junction of both port wine stains and normal skin. Vessels of the port wine stain as well as those of normal skin showed a similar narrow uniform homogeneous line of fluorescence. Granular endothelial staining was seen in the blood vessels of both normal skin and port wine stains. The distribution of fibronectin was that of a low-intensity punctate pattern situated in the subendothelial region of both port wine stain and normal vessels and in the basement membrane zones of hair follicles, endoneurium and perineurium, and the dermoepidermal junction.
针对血管壁三个重要成分（IV型胶原性基底膜蛋白、纤连蛋白和因子VIII）的特异性抗体，被用于研究和比较这些蛋白在正常皮肤和葡萄酒色斑中的分布。胶原性基底膜蛋白定位于葡萄酒色斑和正常皮肤的血管、附属器、立毛肌、神经内膜和神经束膜的基底膜和基底层区域，以及真皮表皮交界处。葡萄酒色斑的血管和正常皮肤的血管均显示出相似的狭窄均匀一致的荧光线条。在正常皮肤和葡萄酒色斑的血管中均可见颗粒状内皮染色。纤连蛋白的分布呈低强度点状模式，位于葡萄酒色斑和正常血管的内皮下区域、毛囊、神经内膜和神经束膜的基底膜区域以及真皮表皮交界处。
