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Role of cytochrome b5 in the cytochrome P-450-mediated C21-steroid 17,20-lyase reaction.

作者信息

Katagiri M, Suhara K, Shiroo M, Fujimura Y

出版信息

Biochem Biophys Res Commun. 1982 Sep 16;108(1):379-84. doi: 10.1016/0006-291x(82)91877-0.

DOI:10.1016/0006-291x(82)91877-0
PMID:6816231
Abstract
摘要

相似文献

1
Role of cytochrome b5 in the cytochrome P-450-mediated C21-steroid 17,20-lyase reaction.细胞色素b5在细胞色素P-450介导的C21-甾体17,20-裂解酶反应中的作用。
Biochem Biophys Res Commun. 1982 Sep 16;108(1):379-84. doi: 10.1016/0006-291x(82)91877-0.
2
Cytochrome b5 promotes the synthesis of delta 16-C19 steroids by homogeneous cytochrome P-450 C21 side-chain cleavage from pig testis.
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3
Reconstitution of steroid 17,20-lyase activity after separation and purification of cytochrome P-450 and its reductase from rat testis microsomes.从大鼠睾丸微粒体中分离纯化细胞色素P-450及其还原酶后甾体17,20-裂解酶活性的重建。
Endocrinology. 1980 Oct;107(4):1055-60. doi: 10.1210/endo-107-4-1055.
4
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.细胞色素b5对库欣综合征患者肾上腺皮质腺瘤中17,20-裂解酶活性调节的体外证据。
Clin Endocrinol (Oxf). 1994 Feb;40(2):205-9. doi: 10.1111/j.1365-2265.1994.tb02469.x.
5
Contribution of cytochrome b5 to androgen synthesis in rat testicular microsomes.细胞色素b5对大鼠睾丸微粒体雄激素合成的作用。
J Biochem. 1984 Feb;95(2):335-43. doi: 10.1093/oxfordjournals.jbchem.a134613.
6
Studies on cytochrome P-450 (P-450 17 alpha,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5.豚鼠肾上腺微粒体细胞色素P-450（P-450 17α，裂解酶）的研究。单一酶的双重功能及细胞色素b5的作用
Biochim Biophys Acta. 1985 Jan 9;833(1):151-60.
7
Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).
J Biol Chem. 1981 Apr 25;256(8):3871-6.
8
Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein.新生猪睾丸微粒体细胞色素P-450：一种蛋白质具有两种酶活性（17α-羟化酶和17,20-裂解酶）
Biochemistry. 1981 Jul 7;20(14):4037-42. doi: 10.1021/bi00517a014.
9
Evidence for involvement of cytochrome P-450-linked oxygenase system in the conversion of C21-steroids to delta 16-C19-steroids catalyzed by pig testicular microsomes.
J Biochem. 1985 Sep;98(3):615-20. doi: 10.1093/oxfordjournals.jbchem.a135317.
10
Random distribution of NADPH-specific flavoprotein and cytochrome P-450 in liver microsomes.
Biochem Biophys Res Commun. 1982 Dec 15;109(3):832-40. doi: 10.1016/0006-291x(82)92015-0.

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Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1).甾体 17α-羟化酶/17,20-裂合酶（细胞色素 P45017A1）。
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Tight binding of cytochrome b to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis.细胞色素 b 与细胞色素 P450 17A1 的紧密结合是刺激 C21 甾体裂解酶活性和雄激素合成的关键特征。
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J Biol Chem. 2019 Jul 12;294(28):10928-10941. doi: 10.1074/jbc.RA119.009305. Epub 2019 May 30.
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Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.睾丸间质细胞中缺乏细胞色素b5的雄性小鼠17,20-裂解酶活性受损。
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