Godin D, Guimond C, Nadeau R A, Leblanc A R
Cardiovasc Res. 1982 Sep;16(9):524-9. doi: 10.1093/cvr/16.9.524.
The contribution of the sympathetic nervous system in the definition of various electrophysiological variables was studied in chemically sympathectomised dogs. Chemical sympathectomy was obtained following intravenous injection of 50 mg X kg-1 of 6-hydroxydopamine. Sympathectomised dogs presented significant increases in: basic sinus period, sino-atrial conduction time (SACT), AH and HV intervals of the His bundle electrogram, atrial functional (AFRP) and effective (AERP) refractory periods, atrio-ventricular node functional (AVNFRP) and effective (AVNERP) refractory periods, ventricular functional (VFRP) and effective (EVRP) refractory periods and atrial (AMAP) and ventricular (VMAP) monophasic action potential durations. Corrected sinus recovery time (CSRT) was not affected by chemical sympathectomy. Neither was the atrial ERP/MAP duration ratio. This new form of sympathectomy affects all the levels of the cardiac conduction system. Such results are in accordance with those obtained with surgical sympathectomy or the use of beta-blocking agents.
在化学性交感神经切除的犬中研究了交感神经系统在各种电生理变量定义中的作用。静脉注射50mg/kg的6-羟基多巴胺后实现化学性交感神经切除。交感神经切除的犬在以下方面显著增加：基础窦性周期、窦房传导时间（SACT）、希氏束电图的AH和HV间期、心房功能（AFRP）和有效（AERP）不应期、房室结功能（AVNFRP）和有效（AVNERP）不应期、心室功能（VFRP）和有效（EVRP）不应期以及心房（AMAP）和心室（VMAP）单相动作电位持续时间。校正的窦房结恢复时间（CSRT）不受化学性交感神经切除的影响。心房ERP/MAP持续时间比值也不受影响。这种新的交感神经切除形式影响心脏传导系统的所有水平。这些结果与手术交感神经切除或使用β受体阻滞剂所获得的结果一致。
