减数分裂染色体行为受黑腹果蝇雌性突变改变的分离影响。
Meiotic chromosome behavior influenced by mutation-altered disjunction in Drosophila melanogaster females.
作者信息
O'Tousa J
出版信息
Genetics. 1982 Nov;102(3):503-24. doi: 10.1093/genetics/102.3.503.
Abstract
The effects of a female-specific meiotic mutation, altered disjunction (ald: 3-61), are described. Although ald females show normal levels of meiotic exchange, sex- and 4th-chromosome nondisjunction occurs at an elevated level. A large proportion of the nondisjunction events is the result of nonhomologous disjunction of the sex and 4th chromosomes. These nonhomologous disjunction events, and probably all nondisjunction events occurring in ald females are the result of two anomalies in chromosome behavior: (1) X chromosomes derived from exchange tetrads undergo nonhomologous disjunction and (2) the 4th chromosomes nonhomologously disjoin from larger chromosomes. There is at best a marginal effect of ald on the meiotic behavior of chromosomes 2 or 3. The results suggest that the ald+ gene product acts to prevent the participation of exchange X chromosomes and all 4th chromosomes in nonhomologous disjunction events. The possible role of ald+ in current models of the disjunction process is considered.
摘要
本文描述了一种雌性特异性减数分裂突变——改变分离（ald: 3-61）的效应。尽管ald雌性个体的减数分裂交换水平正常，但性染色体和第4染色体的不分离现象发生率有所升高。大部分不分离事件是性染色体和第4染色体非同源分离的结果。这些非同源分离事件，可能还有ald雌性个体中发生的所有不分离事件，都是染色体行为出现两种异常的结果：（1）来自交换四分体的X染色体发生非同源分离，（2）第4染色体与较大染色体发生非同源分离。ald对第2或第3染色体的减数分裂行为至多只有轻微影响。结果表明，ald+基因产物的作用是防止发生交换的X染色体和所有第4染色体参与非同源分离事件。文中还探讨了ald+在当前分离过程模型中的可能作用。
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