Sudhir S, Gupta L C, Singh J, Garg K N
Indian J Physiol Pharmacol. 1982 Jul-Sep;26(3):231-4.
Platelet aggregation time was significantly (P less than 0.01) decreased in female rabbits treated with oral contraceptive (a preparation containing low dose of estrogen) as also by injection of diethylstilbestrol (10 mg/kg), while in animals that received indomethacin (10 mg/kg) or aspirin (30 mg/kg) (PG synthetase inhibitors) along with oral contraceptives or diethylstilbestrol there was no significant alteration in platelet aggregation time. The increased synthesis of prostaglandins or some of the intermediary product like TXA2 might be responsible for this effect.
用口服避孕药（一种含低剂量雌激素的制剂）治疗的雌性兔子以及注射己烯雌酚（10毫克/千克）的雌性兔子，其血小板聚集时间显著缩短（P小于0.01），而在接受吲哚美辛（10毫克/千克）或阿司匹林（30毫克/千克）（前列腺素合成酶抑制剂）与口服避孕药或己烯雌酚联合治疗的动物中，血小板聚集时间没有显著变化。前列腺素或某些中间产物如血栓素A2的合成增加可能是造成这种效应的原因。
