黄色粘球菌抗生素TA的化学性质

Chemical properties of Myxococcus xanthus antibiotic TA.

作者信息

Rosenberg E, Fytlovitch S, Carmeli S, Kashman Y

出版信息

J Antibiot (Tokyo). 1982 Jul;35(7):788-93. doi: 10.7164/antibiotics.35.788.

DOI:10.7164/antibiotics.35.788

Abstract

Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (lambda max 239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity.

摘要

抗生素TA是从黄色粘球菌TA的培养液中纯化并结晶得到的。该抗生素（C34H57O9N，分子量623.8）含有以下官能团：酮基、内酯基、仲酰胺基、甲氧基取代二烯（最大吸收波长239nm）、伯醇基和三个仲醇基，其中两个是顺式邻位的。温和的碱性水解会打开内酯环，同时丧失抗生素活性。高碘酸盐氧化也会破坏生物活性。