Minh H N, Smadja A, Orcel L
J Gynecol Obstet Biol Reprod (Paris). 1978 Apr;7(3):387-98.
From the morphological studies that they have carried out the authors describe dysplasias of the cervix of the uterus as a collection of lesions developed from the vestigial cells which are situated at the endo-exocervical junction. The embryological origin of this junction is the sinus. These dysplasias consist of cells with basophil cytoplasm with edges that are not sharp. These form streams which run from the external os of the cervix towards the endocervix, where they replace and disturb the cylindrical epithelium wherever they meet it. These lesions may take on two forms: regular or irregular according to the degree of nucleo-cytoplasmic disharmony. The slow and insidious evolution of these lesions must be distinguished from dystrophic endocervical lesions which are caused by a disturbance in the nutrition of the tissues, which itself is of hormonal or inflammatory origin, and from exocervical lesions which, in common with all lesions of the malpighian mucosa, can undergo atypical scarring.
基于他们所开展的形态学研究，作者将子宫颈发育异常描述为由位于子宫颈内-外口交界处的残留细胞发展而来的一组病变。该交界处的胚胎学起源是窦。这些发育异常由具有嗜碱性细胞质且边缘不清晰的细胞组成。它们形成从子宫颈外口向子宫颈管内延伸的细胞流，在遇到柱状上皮的地方替代并扰乱柱状上皮。根据核质不协调的程度，这些病变可呈现两种形式：规则的或不规则的。必须将这些病变缓慢而隐匿的进展与因组织营养紊乱导致的子宫颈营养不良性病变（其本身源于激素或炎症）以及与马尔皮基黏膜所有病变一样可发生非典型瘢痕形成的子宫颈外病变区分开来。
