de Brux J, Brechet M
Bull Cancer. 1979;66(2):147-53.
During the ten year routing study of smears in 12,300 pregnant women, 180 cases of atypias of the uterine cervix were detected (1.46%). However, only 106 of these had sufficient follow up to allow us to draw useful conclusions. The lesions detected included: 1 invasive carcinoma, 71 atypical epithelial lesions and 34 border lesions of which 20 (58%) showed improvement and 14 (41%) remained unchanged. A comparative sutdy of 11,090 sexually active women who were on high oestrogen combination pills, revealed a similar incidence of cervical lesions (1.27%). The lesions included: 2 invasive carcinomas, 100 epithelial atypias and 38 border lesions of which 44 per cent showed improvement and 55 per cent remained unchanged. Cervical lesions were detected in only 0.5 per cent of women on law oestrogen combination pills. These results indicate that it is almost impossible for the cytologist to arrive at a diagnosis of carcinoma in situ in the pregnant woman or in the woman on the pill. No morphologic guide exists to help establish a prognosis. Only follow up study of the cervical lesion is valuable in this regard. Any lesion remaining 6 to 12 months after the delivery should be removed.
在对12300名孕妇进行的为期十年的涂片常规研究中，检测到180例宫颈非典型病变（1.46%）。然而，其中只有106例有足够的随访资料，使我们能够得出有用的结论。检测到的病变包括：1例浸润癌、71例非典型上皮病变和34例临界病变，其中20例（58%）病情好转，14例（41%）病情未变。对11090名服用高雌激素复方避孕药的性活跃女性进行的一项对比研究显示，宫颈病变的发生率相似（1.27%）。病变包括：2例浸润癌、100例上皮非典型病变和38例临界病变，其中44%病情好转，55%病情未变。服用低雌激素复方避孕药的女性中，宫颈病变的检出率仅为0.5%。这些结果表明，细胞学家几乎不可能对孕妇或服用避孕药的女性做出原位癌的诊断。不存在有助于判断预后的形态学依据。在这方面，对宫颈病变进行随访研究才有价值。产后6至12个月仍存在的任何病变都应切除。
