Nathan R S, Sachar E J, Tabrizi M A, Asnis G M, Halbreich U, Halpern F S
Psychoneuroendocrinology. 1982;7(2-3):235-8. doi: 10.1016/0306-4530(82)90018-x.
Bolus injections of synthetic thyrotropin-releasing hormone (TRH) were administered to five young normal men in the morning (0900 hr) and the evening (1800 hr) on different days. Frequent blood samples for prolactin (PRL) and TSH analyses were collected before and after TRH infusion. Although there were no differences between the morning and the evening basal PRL levels, a significantly greater PRL response to TRH in the evening was observed (delta PRL, a.m. vs p.m., p less than 0.025). Since TRH stimulates PRL through a direct effect on the pituitary, our data suggest that there is a diurnal variation in the pituitary lactotroph responsiveness to TRH. On the other hand, a.m. and p.m. basal and TRH-stimulated TSH responses were virtually identical.
在不同日期的上午（09:00）和晚上（18:00），对五名年轻正常男性进行了合成促甲状腺激素释放激素（TRH）的静脉推注。在TRH输注前后采集了频繁的血样用于催乳素（PRL）和促甲状腺激素（TSH）分析。虽然上午和晚上的基础PRL水平没有差异，但观察到晚上对TRH的PRL反应明显更大（PRL变化量，上午与下午相比，p<0.025）。由于TRH通过对垂体的直接作用刺激PRL，我们的数据表明垂体催乳细胞对TRH的反应存在昼夜变化。另一方面，上午和下午的基础及TRH刺激的TSH反应几乎相同。
