Caroff S N, Winokur A
Biol Psychiatry. 1984 Jul;19(7):1015-25.
The prolactin (PRL) and thyrotropin (TSH) response to an intravenous dose (400 micrograms) of thyrotropin-releasing hormone (TRH) was studied in eight healthy young men in the morning (0800 hr), in the evening (2000 hr), and after an acute 12-hr shift of the rest-activity cycle. The PRL and TSH response to TRH was significantly greater in the evening than the morning. The increased PRL and TSH responses observed in the evening were significantly reduced following rest-activity reversal. Our findings underscore the importance of temporal factors in determining response to TRH. These factors may be relevant in clarifying the mechanisms underlying abnormal hormonal responses to TRH in patients with affective disorders.
在8名健康年轻男性中，研究了清晨（08:00）、傍晚（20:00）以及在休息 - 活动周期急性12小时转换后，静脉注射一剂（400微克）促甲状腺激素释放激素（TRH）后催乳素（PRL）和促甲状腺激素（TSH）的反应。TRH刺激后PRL和TSH的反应在傍晚明显大于清晨。休息 - 活动周期颠倒后，傍晚观察到的PRL和TSH反应增强明显减弱。我们的研究结果强调了时间因素在决定对TRH反应中的重要性。这些因素可能与阐明情感障碍患者对TRH激素反应异常的潜在机制有关。
