6,9-二环氧-6,9-N-苯基亚氨基-δ6,8-前列环素I1的合成。一种白三烯C和D合成的新型抑制剂。
The synthesis of 6,9-deepoxy-6,9-N-phenylimino-delta 6,8-prostaglandin I1. A novel inhibitor of leukotriene C and D synthesis.
作者信息
Smith H W, Bach M K, Harrison A W, Johnson H G, Major N J, Wasserman M A
出版信息
Prostaglandins. 1982 Oct;24(4):543-6. doi: 10.1016/0090-6980(82)90012-0.
PMID:6817384
Abstract
The pyrrole analog of prostacyclin, 6,9-deepoxy-6,9-N-phenylimino-delta 6,8-prostaglandin I1 was synthesized from PGF2 alpha methyl ester. This pyrroloprostacyclin (U-60,257) and its methyl ester (U-56,467) have been shown to inhibit leukotriene C/D biosynthesis and antagonize leukotriene C/D contractions in vitro. Antigen induced bronchopulmonary changes in monkeys and guinea pigs are inhibited by U-60,257 in vivo.
摘要
前列环素的吡咯类似物，6,9-二环氧-6,9-N-苯基亚氨基-δ6,8-前列环素I1由PGF2α甲酯合成。这种吡咯前列环素（U-60,257）及其甲酯（U-56,467）已被证明在体外可抑制白三烯C/D的生物合成并拮抗白三烯C/D引起的收缩。在体内，U-60,257可抑制抗原诱导的猴子和豚鼠的支气管肺变化。
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