Patterson K G, Goldstone A H, Richards J D, Cawley J C
Acta Haematol. 1982;68(4):261-7. doi: 10.1159/000206991.
A case of acute myeloid leukaemia (AML) (M2 type) is described in which the neutrophil population contained markedly increased peroxidase activity. The increased peroxidase activity was initially detected during routine counting with the Hemalog D automated differential counter and the increased enzyme staining was confirmed by manual and ultrastructural cytochemistry. The abnormal neutrophil population persisted after blast cells had disappeared from the blood and until marrow hypoplasia was induced by chemotherapy. When remission emerged, the peroxidase activity of the neutrophil population was normal. At subsequent relapse, the neutrophil population with increased peroxidase activity reappeared and with the induction of second remission neutrophil peroxidase again returned to normal. In 8 other cases where sufficient neutrophils were present for analysis by the Hemalog D, neutrophil peroxidase was normal or not increased in 7 cases, but was markedly reduced in 1 case of AML (M6 type). It is suggested that abnormalities of neutrophil peroxidase activity detected by the Hemalog D may serve as useful leukaemic markers.
本文描述了一例急性髓系白血病（AML）（M2型），其中性粒细胞群体的过氧化物酶活性显著增加。过氧化物酶活性增加最初是在使用Hemalog D自动血细胞分析仪进行常规计数时检测到的，并且通过手工和超微结构细胞化学证实了酶染色增加。原始细胞从血液中消失后，异常中性粒细胞群体持续存在，直至化疗诱导骨髓发育不全。当出现缓解时，中性粒细胞群体的过氧化物酶活性正常。在随后的复发时，过氧化物酶活性增加的中性粒细胞群体再次出现，并且随着第二次缓解的诱导，中性粒细胞过氧化物酶再次恢复正常。在其他8例有足够中性粒细胞可供Hemalog D分析的病例中，7例中性粒细胞过氧化物酶正常或未增加，但在1例AML（M6型）中显著降低。提示通过Hemalog D检测到的中性粒细胞过氧化物酶活性异常可能作为有用的白血病标志物。
