Schellekens H, van Eerd P M, de Reus A, Weck P K, Stebbing N
Antiviral Res. 1982 Oct;2(5):313-8. doi: 10.1016/0166-3542(82)90054-7.
Human interferon type alpha 2 (HuIFN-alpha 2) produced by Escherichia coli was found to be as active as natural leukocyte interferon in protecting rhesus monkeys against intradermal vaccinia virus infection. HuIFN-beta 1 produced in E. coli had similar but less pronounced activity. HuIFN-alpha 2 induced fever but not leukopenia, while HuIFN-beta 1 had opposite effects. Concurrent treatment with acetosalicylic acid and prednisolone/azothioprine combinations did not interfere with the efficacy of the human interferons.
