α-干扰素2、盐酸金刚烷胺和利巴韦林联合使用对流感病毒体外复制的抑制作用
Combined interferon-alpha 2, rimantadine hydrochloride, and ribavirin inhibition of influenza virus replication in vitro.
作者信息
Hayden F G, Schlepushkin A N, Pushkarskaya N L
出版信息
Antimicrob Agents Chemother. 1984 Jan;25(1):53-7. doi: 10.1128/AAC.25.1.53.
Abstract
Recombinant DNA-produced human interferon-alpha 2 inhibited the replication of influenza A and B viruses in primary rhesus monkey kidney cells (RMK). Human interferon-alpha 2 interacted additively or synergistically with rimantadine hydrochloride or ribavirin in reducing the yield of clinical isolates of either H3N2 or H1N1 subtype influenza A viruses. The combination of human interferon-alpha 2 and ribavirin also inhibited the replication of an influenza B virus to a greater extent than either single agent. In addition to drug concentration, the virus inoculum and duration of culture were important variables in determining the degree of inhibition. Single drugs or combinations did not significantly inhibit the growth of uninfected RMK cells, which indicated that the observed interactions with respect to antiviral activity were not due to cell cytotoxicity.
摘要
重组DNA制备的人α-2干扰素可抑制甲型和乙型流感病毒在原代恒河猴肾细胞（RMK）中的复制。在降低H3N2或H1N1亚型甲型流感病毒临床分离株的产量方面，人α-2干扰素与盐酸金刚烷胺或利巴韦林呈相加或协同作用。人α-2干扰素与利巴韦林联合使用时，对乙型流感病毒复制的抑制程度也大于单一药物。除药物浓度外，病毒接种量和培养时间也是决定抑制程度的重要变量。单一药物或联合用药均未显著抑制未感染的RMK细胞的生长，这表明观察到的抗病毒活性相互作用并非由于细胞毒性。
相似文献
1
Combined interferon-alpha 2, rimantadine hydrochloride, and ribavirin inhibition of influenza virus replication in vitro.α-干扰素2、盐酸金刚烷胺和利巴韦林联合使用对流感病毒体外复制的抑制作用
Antimicrob Agents Chemother. 1984 Jan;25(1):53-7. doi: 10.1128/AAC.25.1.53.
2
[Effect of remantadine, ribavirin and their combinations on the protein synthesis of influenza virus A in a cell culture].[金刚乙胺、利巴韦林及其联合用药对细胞培养中甲型流感病毒蛋白质合成的影响]
Vopr Med Khim. 1981 Nov-Dec;27(6):820-3.
3
4
[Sensitivity to remantadine and ribavirin of influenza A virus resistant to 2-(1'-aminoethyl)-bicyclo(2.2.1)heptane hydrochloride].
Vopr Virusol. 1984 Sep-Oct;29(5):619-21.
5
[Study of the antiviral activity of Russian anti-influenza agents in cell culture and animal models].[俄罗斯抗流感药物在细胞培养和动物模型中的抗病毒活性研究]
Vopr Virusol. 2010 May-Jun;55(3):19-27.
6
Enhancement of activity against influenza viruses by combinations of antiviral agents.抗病毒药物联合使用增强对流感病毒的活性。
Antimicrob Agents Chemother. 1980 Oct;18(4):536-41. doi: 10.1128/AAC.18.4.536.
7
[Antiviral action of sodium selenite and its combination with remantadine].[亚硒酸钠的抗病毒作用及其与金刚烷胺的联合应用]
Vopr Virusol. 1987 Nov-Dec;32(6):670-5.
8
Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro.利巴韦林单独或与人α干扰素联合对猫传染性腹膜炎病毒体外复制的抑制作用。
Vet Microbiol. 1989 Jul;20(3):255-65. doi: 10.1016/0378-1135(89)90049-7.
9
[Change in the sensitivity of influenza virus, replicating in the presence of rimantadine, to antiviral agents].[在金刚乙胺存在的情况下复制的流感病毒对抗病毒剂敏感性的变化]
Vopr Virusol. 1999 May-Jun;44(3):115-9.
10
引用本文的文献
1
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches.抗流感病毒的策略：已批准和创新治疗方法的最新进展
Cell Mol Life Sci. 2025 Feb 13;82(1):75. doi: 10.1007/s00018-025-05611-1.
2
Antiviral options and therapeutics against influenza: history, latest developments and future prospects.抗流感病毒的选择和治疗方法：历史、最新进展和未来前景。
Front Cell Infect Microbiol. 2023 Nov 29;13:1269344. doi: 10.3389/fcimb.2023.1269344. eCollection 2023.
3
Antiviral Approaches against Influenza Virus.抗流感病毒的策略。
Clin Microbiol Rev. 2023 Mar 23;36(1):e0004022. doi: 10.1128/cmr.00040-22. Epub 2023 Jan 16.
4
Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead.用于呼吸道感染的吸入式抗感染化疗：成就、挑战与未来之路。
Adv Drug Deliv Rev. 2015 May;85:65-82. doi: 10.1016/j.addr.2014.11.004. Epub 2014 Nov 12.
5
Antiviral combinations for severe influenza.用于重症流感的抗病毒联合疗法。
Lancet Infect Dis. 2014 Dec;14(12):1259-70. doi: 10.1016/S1473-3099(14)70821-7. Epub 2014 Sep 8.
6
Stimulation with the Aureobasidium pullulans-produced β-glucan effectively induces interferon stimulated genes in macrophage-like cell lines.经 Aureobasidium pullulans 产生的β-葡聚糖刺激可有效诱导巨噬样细胞系中的干扰素刺激基因。
Sci Rep. 2014 Apr 24;4:4777. doi: 10.1038/srep04777.
7
Newer influenza antivirals, biotherapeutics and combinations.新型流感抗病毒药物、生物制剂及联合用药。
Influenza Other Respir Viruses. 2013 Jan;7 Suppl 1(Suppl 1):63-75. doi: 10.1111/irv.12045.
8
Therapeutics against influenza.流感治疗方法。
Curr Top Microbiol Immunol. 2013;370:273-300. doi: 10.1007/82_2011_198.
9
Combination chemotherapy for influenza.流感的联合化疗。
Viruses. 2010 Aug;2(8):1510-1529. doi: 10.3390/v2081510. Epub 2010 Jul 27.
10
Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.金刚烷胺、利巴韦林和奥司他韦三联用药对体外耐药流感病毒株具有高度活性和协同作用。
PLoS One. 2010 Feb 22;5(2):e9332. doi: 10.1371/journal.pone.0009332.
本文引用的文献
1
Absence of interferon in lungs fom fatal cases of influenza.致命性流感病例肺部中干扰素的缺失。
Br Med J. 1962 Jan 6;1(5270):18-20. doi: 10.1136/bmj.1.5270.18.
2
Enhancement of activity against influenza viruses by combinations of antiviral agents.抗病毒药物联合使用增强对流感病毒的活性。
Antimicrob Agents Chemother. 1980 Oct;18(4):536-41. doi: 10.1128/AAC.18.4.536.
3
Plaque inhibition assay for drug susceptibility testing of influenza viruses.用于流感病毒药物敏感性测试的噬斑抑制试验。
Antimicrob Agents Chemother. 1980 May;17(5):865-70. doi: 10.1128/AAC.17.5.865.
4
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.金刚烷胺和利巴韦林气雾剂对小鼠甲型和乙型流感感染的治疗作用
Antimicrob Agents Chemother. 1980 Apr;17(4):642-8. doi: 10.1128/AAC.17.4.642.
5
Lack of effect of oral ribavirin in naturally occurring influenza A virus (H1N1) infection.口服利巴韦林对自然发生的甲型流感病毒（H1N1）感染无效。
J Infect Dis. 1980 May;141(5):548-54. doi: 10.1093/infdis/141.5.548.
6
Therapeutic effects of aerosolized amantadine in naturally acquired infection due to influenza A virus.雾化吸入金刚烷胺对甲型流感病毒自然感染的治疗作用。
J Infect Dis. 1980 May;141(5):535-42. doi: 10.1093/infdis/141.5.535.
7
8
Comparative therapeutic effect of aerosolized and oral rimantadine HCl in experimental human influenza A virus infection.雾化吸入与口服盐酸金刚烷胺对实验性甲型流感病毒感染的比较治疗效果
Antiviral Res. 1982 Aug;2(3):147-53. doi: 10.1016/0166-3542(82)90016-x.
9
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.一项关于金刚烷胺和金刚乙胺预防甲型流感感染的对照试验。
N Engl J Med. 1982 Sep 2;307(10):580-4. doi: 10.1056/NEJM198209023071002.
10
Successful treatment of naturally occurring influenza A/USSR/77 H1N1.成功治疗自然发生的甲型流感/苏联/77 H1N1。
JAMA. 1981 Mar 20;245(11):1128-31. doi: 10.1001/jama.245.11.1128.
Zotero 插件