Volpe A, Mazza V, Di Renzo G C
Int J Biol Res Pregnancy. 1982;3(4):161-6.
Prolactin levels were evaluated during certain stress conditions, obstetric or gynecologic surgical interventions, labor, and birth. In 68 patients undergoing voluntary abortion, prolactin levels were measured to study the effect of anesthetics and of dilatation and curettage on hormonal secretion. Prolactin levels were evaluated in five patients undergoing elective cesarean section and in five post-menopausal patients undergoing total abdominal hysterectomy with bilateral oophorectomy. Moreover, prolactin concentration in serial samples of blood was estimated in 32 normal patients with spontaneous vaginal delivery at term and in 16 newborns at term after 30-60 and 120 min following birth. Prolactin responsiveness to TRH was evaluated in 12 newborns at the 4th day of life. Plasma prolactin levels rose in all the stress conditions investigated except in labor, during which hormone levels showed a decrease starting 2 h before delivery and reaching the lowest value 1 h prior. From this moment on there was a remarkable rise in prolactin concentration, with a peak 1 h after delivery. The decrease in prolactin levels during labor could possibly be due to an increase in dopaminergic activity. Moreover, the finding of no variation of prolactin levels during induced abortion in a group of patients pretreated with methysergide supports the view that the serotoninergic system also affects prolactin release.
在某些应激状态、妇产科手术干预、分娩及生产过程中对催乳素水平进行了评估。对68例行自愿堕胎的患者测量了催乳素水平，以研究麻醉剂以及刮宫术对激素分泌的影响。对5例行择期剖宫产的患者以及5例行全腹子宫切除加双侧卵巢切除术的绝经后患者的催乳素水平进行了评估。此外，对32例足月自然阴道分娩的正常患者以及16例足月新生儿出生后30 - 60分钟和120分钟时的系列血样中的催乳素浓度进行了估计。对12例出生第4天的新生儿评估了催乳素对促甲状腺激素释放激素（TRH）的反应性。在所研究的所有应激状态下，血浆催乳素水平均升高，但分娩期间除外，在分娩前2小时起激素水平开始下降，并在分娩前1小时降至最低值。从此时起，催乳素浓度显著升高，在分娩后1小时达到峰值。分娩期间催乳素水平下降可能是由于多巴胺能活性增加所致。此外，在用麦角新碱预处理的一组患者中，人工流产期间催乳素水平无变化这一发现支持了血清素能系统也影响催乳素释放的观点。
