Pohjavuori M, Rovamo L, Laatikainen T, Kariniemi V, Pettersson J
Biol Res Pregnancy Perinatol. 1986;7(1):1-5.
Cord plasma levels of endorphins and catecholamines were correlated with the values of cord blood gas analysis and with hemodynamic parameters in 11 newborns (group A) delivered by elective cesarean section and in 18 newborns (group B) born spontaneously by vaginal route. All infants were in a good condition. No statistically significant differences were found in the mean cord plasma levels of adrenaline (A), noradrenaline (NA) and immunoreactive beta-endorphin (ir beta-E) between groups A and B. After spontaneous labor in group B a highly significant negative correlation was found between plasma NA level and pH and a positive correlation between NA and carbon dioxide tension in cord arterial blood and between NA and the short-term variability of the fetal heart rate before birth. Cord plasma A and ir beta-E did not show such correlations. These findings show that cord plasma level of NA is a sensitive indicator of minor stress during normal labor. After birth, during the first two hours of life, the mean plasma level of ir beta-E decreased in group B after vaginal delivery, but remained at a higher level in group A after elective cesarean section. This shows that the mode of delivery influences the neonatal endorphin secretion.
对11例择期剖宫产出生的新生儿（A组）和18例经阴道自然分娩的新生儿（B组），研究了其脐血血浆中内啡肽和儿茶酚胺水平与脐血气分析值及血流动力学参数之间的相关性。所有婴儿状况良好。A组和B组之间，肾上腺素（A）、去甲肾上腺素（NA）和免疫反应性β-内啡肽（irβ-E）的脐血浆平均水平未发现统计学上的显著差异。B组自然分娩后，脐动脉血中血浆NA水平与pH呈高度显著负相关，NA与二氧化碳分压以及NA与出生前胎儿心率短期变异性之间呈正相关。脐血浆A和irβ-E未显示出此类相关性。这些发现表明，脐血浆NA水平是正常分娩期间轻微应激的敏感指标。出生后，在生命的头两个小时内，B组经阴道分娩后irβ-E的平均血浆水平下降，但A组择期剖宫产后仍保持在较高水平。这表明分娩方式会影响新生儿内啡肽的分泌。
