Rangala N, Cox J D, Byhardt R W, Wilson J F, Greenberg M, Lopes da Conceicao A
Int J Radiat Oncol Biol Phys. 1982 Nov;8(11):1909-14. doi: 10.1016/0360-3016(82)90449-7.
From 1966 through 1978, 128 patients with biopsy-proven adenocarcinoma of the prostate underwent external irradiation to the entire pelvis followed by additional irradiation with a field that encompassed the entire prostate with generous margins. Local recurrence was diagnosed when palpable regrowth occurred and was confirmed by biopsy. Eighteen patients (14%) had local recurrence. Actuarial (life table) local recurrence rates, however, were 24% for both for Stage B and C patients. Actuarial five year survival was 100% for the 10 Stage A patients, 91% for the 25 Stage B, and 78% for the 93 Stage C patients. Actuarial five year disease-free survival was 59% for Stage B and 69% for Stage C patients. Local recurrence was affected by the total dose to the whole pelvis and the dose at the center of the prostate. Disease-free survival was influenced by differentiation. High dose external irradiation to the prostate and regional lymph nodes offers the greatest probability of long-term disease-free survival for patients with localized disease. Late bowel complications were seen in 14 patients (11%), two of whom required colostomies. Late urinary tract complications were observed in five patients (4%).
从1966年到1978年，128例经活检证实为前列腺腺癌的患者接受了全盆腔外照射，随后用一个包含整个前列腺且有足够边缘的野进行追加照射。当可触及肿瘤复发时诊断为局部复发，并通过活检确诊。18例患者（14%）发生局部复发。然而，B期和C期患者的精算（生命表）局部复发率均为24%。10例A期患者的精算5年生存率为100%，25例B期患者为91%，93例C期患者为78%。B期患者的精算5年无病生存率为59%，C期患者为69%。局部复发受全盆腔总剂量和前列腺中心剂量的影响。无病生存受分化程度影响。对前列腺和区域淋巴结进行高剂量外照射为局限性疾病患者提供了长期无病生存的最大可能性。14例患者（11%）出现晚期肠道并发症，其中2例需要行结肠造口术。5例患者（4%）观察到晚期泌尿系统并发症。
