Gilmore D S, Bruce S K, Jimenez E M, Schick D G, Morrow J W, Montgomerie J Z
J Clin Microbiol. 1982 Nov;16(5):856-60. doi: 10.1128/jcm.16.5.856-860.1982.
The prevalence of Pseudomonas aeruginosa colonization of patients with spinal cord injury was studied annually from 1976 to 1980. The urethra, perineum, rectum, drainage bag, and urine of patients on the spinal cord injury service were cultured. A total of 224 men and 32 women were studied. Most patients were managed with an external urinary collection system or padding, with or without intermittent catheterization. P. aeruginosa was cultured from one or more body sites (urethra, perineum, or rectum) in 65% of men and 18% of women. Drainage bags on the beds were frequently colonized with P. aeruginosa (73%). Significant bacteriuria with P. aeruginosa was present in 19% of the men and 13% of the women. P. aeruginosa colonization of body sites in men was closely associated with the use of an external urinary collection system. Significantly greater urethral and perineal colonization was found in men using an external urinary collection system. P. aeruginosa serotype 11 was the predominant serotype for the first 3 years, and the number of patients colonized with serotype 11 increased with length of hospital stay. The prevalence of serotype 11 significantly decreased in the last 2 years. The antibiotic susceptibility of the strains of P. aeruginosa isolated from these patients did not change in the 5 years, except that there was increasing susceptibility to carbenicillin in later years. This increasing susceptibility to carbenicillin was a reflection of a decreased prevalence of serotype 11 in these patients, since serotype 11 was more resistant than other serotypes to carbenicillin.
1976年至1980年期间，每年对脊髓损伤患者的铜绿假单胞菌定植情况进行研究。对脊髓损伤病房患者的尿道、会阴、直肠、引流袋及尿液进行培养。共研究了224名男性和32名女性。大多数患者采用外置尿液收集系统或垫子进行处理，有或没有间歇性导尿。65%的男性和18%的女性在一个或多个身体部位（尿道、会阴或直肠）培养出铜绿假单胞菌。床上的引流袋经常被铜绿假单胞菌定植（73%）。19%的男性和13%的女性存在铜绿假单胞菌显著菌尿。男性身体部位的铜绿假单胞菌定植与使用外置尿液收集系统密切相关。使用外置尿液收集系统的男性尿道和会阴定植明显更多。11型铜绿假单胞菌在前3年是主要血清型，且11型定植患者数量随住院时间延长而增加。在最后2年，11型的流行率显著下降。从这些患者中分离出的铜绿假单胞菌菌株的抗生素敏感性在5年中没有变化，只是在后期对羧苄青霉素的敏感性增加。这种对羧苄青霉素敏感性的增加反映了这些患者中11型流行率的下降，因为11型比其他血清型对羧苄青霉素更耐药。
