Takala J
JPEN J Parenter Enteral Nutr. 1982 Sep-Oct;6(5):388-91. doi: 10.1177/0148607182006005388.
The metabolic and nutritional effects of long-term parenteral and enteral nutrition were studied in two infants and one child with severe growth failure due to chronic renal failure (two patients) and congenital nephrosis (one patient). Six periods of treatment were analyzed. Both the parenteral nutrition and continuous enteral nutrition were found efficient in enhancing growth and correcting the metabolic abnormalities of uremia. The beneficial effects of this intensive nutrition were smaller in congenital nephrosis, although growth accelerated. Nitrogen balance studies confirmed effective nutrient utilization. The serum levels of calcium and phosphate were normalized as anabolism was achieved in the uremia. In fact, the rapid development of severe hypophosphatemia in one of the patients proved that the "fatal hyperalimentation syndrome" appears to be a specific threat in parenteral nutrition applied in uremia.
对两名因慢性肾衰竭（两名患者）和先天性肾病（一名患者）而严重生长发育迟缓的婴儿和一名儿童，研究了长期肠外营养和肠内营养的代谢及营养作用。分析了六个治疗阶段。发现肠外营养和持续肠内营养在促进生长及纠正尿毒症的代谢异常方面均有效。尽管生长加速，但这种强化营养在先天性肾病中的有益作用较小。氮平衡研究证实了营养物质的有效利用。随着尿毒症患者合成代谢的实现，血清钙和磷水平恢复正常。事实上，其中一名患者迅速出现严重低磷血症，证明“致命性高营养综合征”似乎是尿毒症患者肠外营养中一种特殊的威胁。
