Portelli C
Physiologie. 1982 Oct-Dec;19(4):229-31.
The excess of the potassium, magnesium or hydrogen ions, as well as the diminution of the sodium ions concentration in the perfusion fluid can block the electrical and mechanical activities of the isolated heart of frog. These effects can be eliminated by a concomitant increase in the concentration of the calcium, sodium, or hydroxyl ions. The above-mentioned results suggest the existence of two types of ionic constellations, which are antagonistic: one formed from magnesium and potassium ions and functioning in a medium with an acid pH, and another one formed from calcium and sodium ions and functioning in an alkaline medium.
灌注液中钾离子、镁离子或氢离子过量,以及钠离子浓度降低,均可阻断青蛙离体心脏的电活动和机械活动。伴随钙离子、钠离子或氢氧根离子浓度升高,这些效应可被消除。上述结果提示存在两种相互拮抗的离子组合类型:一种由镁离子和钾离子构成,在酸性pH介质中起作用;另一种由钙离子和钠离子构成,在碱性介质中起作用。