O'Donnell J M, Seiden L S
Psychopharmacology (Berl). 1982;78(3):214-8. doi: 10.1007/BF00428153.
The effects of three monoamine oxidase inhibitors (MAOI) on performance under a differential-reinforcement-of-low-rate 72-s schedule (DRL 72-s) for water reinforcement were determined. All three drugs (isocarboxazid, iproniazid, phenelzine) reduced response rate and increased reinforcement rate in rats performing under the DRL schedule. Drugs from other classes (alcohol, chlordiazepoxide, morphine, pentobarbital) did not produce similar effects. The ability of MAOI to increase reinforcement rate under a DRL 72-s schedule is similar to that recently reported for tricyclic antidepressants and the two atypical antidepressants mianserin and iprindole. These findings support the contention that the DRL schedule may be useful as a test for identifying new antidepressants and for elucidating the neurochemical effects of antidepressants that are responsible for their therapeutic actions.
研究了三种单胺氧化酶抑制剂（MAOI）对大鼠在以水为强化物的低速率72秒差别强化程序（DRL 72-s）下行为表现的影响。所有三种药物（异卡波肼、异烟肼、苯乙肼）均降低了大鼠在DRL程序下的反应率，并提高了强化率。其他类型的药物（酒精、氯氮卓、吗啡、戊巴比妥）未产生类似效果。MAOI在DRL 72-s程序下提高强化率的能力与最近报道的三环类抗抑郁药以及两种非典型抗抑郁药米安色林和茚满二酮相似。这些发现支持了这样的观点，即DRL程序可能有助于作为一种测试，用于识别新的抗抑郁药以及阐明导致抗抑郁药治疗作用的神经化学效应。
