Shea V T
Psychopharmacology (Berl). 1982;78(3):266-70. doi: 10.1007/BF00428163.
Methylphenidate state-dependent learning was investigated using a paired-associate learning task of 16 pairs of pictures. Subjects were 15 children for whom methylphenidate was currently being prescribed. Each child was seen for two learning sessions and two testing sessions. Learning took place under placebo and under the child's regular dosage of methylphenidate. During retention testing all combinations of learning drug-state and testing drug-state were observed for each child. Data were analyzed using contrast variables which took into account the repeated-measures nature of the design. The results indicated that there was a trend in the direction of state-dependence in the whole sample. Significant symmetrical state-dependent effects were obtained in those subjects whose original learning was facilitated by methylphenidate.
使用16对图片的配对联想学习任务研究了哌甲酯的状态依赖性学习。受试者为15名目前正在服用哌甲酯的儿童。每个孩子都接受了两次学习课程和两次测试课程。学习在安慰剂和孩子常规剂量的哌甲酯条件下进行。在记忆测试期间，观察了每个孩子学习药物状态和测试药物状态的所有组合。使用考虑了设计重复测量性质的对比变量对数据进行分析。结果表明，整个样本中存在状态依赖性的趋势。在那些原始学习因哌甲酯而得到促进的受试者中获得了显著的对称状态依赖性效应。
