Becker-Mattes A, Mattes J A, Abikoff H, Brandt L
Am J Psychiatry. 1985 Apr;142(4):455-9. doi: 10.1176/ajp.142.4.455.
State-dependent learning refers to a failure of learning mastered under one drug condition to be remembered when tested under another drug condition. Previous studies of state-dependent learning in hyperactive children receiving stimulants have yielded conflicting results. The authors systematically evaluated learning and transfer of learning in children who were or were not receiving methylphenidate and included several design features intended to optimize the likelihood of demonstrating state-dependent learning. They found no evidence of state-dependent learning. These results diminish concern regarding state-dependent effects in hyperactive children who are positive drug responders and who are clinically administered methylphenidate to control their hyperactivity.
状态依赖学习是指在一种药物状态下掌握的学习内容，在另一种药物状态下进行测试时无法被记住。先前对接受兴奋剂治疗的多动症儿童的状态依赖学习研究得出了相互矛盾的结果。作者系统地评估了接受或未接受哌甲酯的儿童的学习及学习迁移情况，并纳入了几个旨在优化证明状态依赖学习可能性的设计特征。他们没有发现状态依赖学习的证据。这些结果减轻了对于那些对药物反应良好且临床上使用哌甲酯来控制多动症的多动症儿童出现状态依赖效应的担忧。
