Landauer M R, Balster R L
Psychopharmacology (Berl). 1982;78(4):322-5. doi: 10.1007/BF00433734.
A new automated device that concurrently records social investigatory responses and spontaneous motor activity is described and the effects of d-amphetamine are presented. The rectangular Plexiglas apparatus was divided into three compartments, separated from each other by wire mesh screens. A male mouse was placed into the center compartment and the amount of time spent investigating the two adjacent stimulus compartments was recorded using contact circuits. One stimulus compartment housed a female conspecific, while the other remained uninhabited and served as a control for nonsocial investigatory responses. A photo-cell bisected the center compartment and recorded motor activity. Doses of 0, 0.3, 1.0, and 3.0 mg/kg d-amphetamine administered to both sexually naive and sexually experienced male mice resulted in a dose-dependent decrease in investigation of both stimulus chambers, however social investigation was significantly affected at a lower dose. Both groups of males preferred the female to the uninhabited chamber at all but the highest dose of d-amphetamine, which abolished the preference. Locomotor activity for both inexperienced and experienced males increased with increasing doses of d-amphetamine.
本文描述了一种新的自动化装置，该装置可同时记录社会探究反应和自发运动活动，并展示了d-苯丙胺的作用效果。矩形有机玻璃装置被分为三个隔室，由金属丝网相互隔开。将一只雄性小鼠放入中间隔室，使用接触电路记录其探究两个相邻刺激隔室所花费的时间。一个刺激隔室中有一只同种雌性小鼠，另一个则无人居住，用作非社会探究反应的对照。一个光电管将中间隔室一分为二，并记录运动活动。对性幼稚和有性经验的雄性小鼠分别给予0、0.3、1.0和3.0mg/kg的d-苯丙胺剂量，结果导致对两个刺激隔室的探究均呈剂量依赖性减少，然而，在较低剂量时社会探究受到显著影响。除了最高剂量的d-苯丙胺消除了偏好外，两组雄性小鼠在所有剂量下都更喜欢雌性小鼠所在的隔室，而不是无人居住的隔室。随着d-苯丙胺剂量的增加，无经验和有经验雄性小鼠的运动活动均增加。
