Dolva L O, Hanssen K F, Flaten O, Skare S, Schrumpf E
Scand J Gastroenterol. 1982 Sep;17(6):775-80. doi: 10.3109/00365528209181092.
Thyrotropin-releasing hormone (TRH) has been shown to have a dose-dependent inhibiting effect on the pentagastrin-stimulated gastric acid secretion in man. We studied the effect of increasing doses of TRH on the gastric acid secretion stimulated by a submaximal histamine dose. The effect of a relatively high dose of TRH (500 micrograms/h) on the maximal histamine-stimulated acid secretion was examined. Furthermore, we studied the effect of two doses of TRH (40 micrograms/h and 500 micrograms/h) on the gastric acid output after insulin-induced hypoglycemia. A significant reduction of the submaximal histamine-stimulated gastric acid output was observed during infusion of 8 micrograms/h TRH (16%), 40 micrograms/h TRH (38%), and 200 micrograms/h TRH (42%) (percentage reduction compared with the control experiment). TRH, 1000 micrograms/h, had no significant effect. With regard to the acid output after maximal histamine stimulation, TRH 500 micrograms/h was without significant effect. After hypoglycemia the acid output was reduced by 30% during 40 micrograms/h TRH (p less than 0.05) and by 37% during 500 micrograms/h TRH (p less than 0.02). TRH had no effect on the acid concentration in any of the studies. The possible mechanisms by which TRH may interact with the acid regulation are discussed.
促甲状腺激素释放激素（TRH）已被证明对人体中五肽胃泌素刺激的胃酸分泌具有剂量依赖性抑制作用。我们研究了递增剂量的TRH对次最大组胺剂量刺激的胃酸分泌的影响。检测了相对高剂量的TRH（500微克/小时）对最大组胺刺激的胃酸分泌的影响。此外，我们研究了两种剂量的TRH（40微克/小时和500微克/小时）对胰岛素诱导的低血糖后胃酸分泌量的影响。在输注8微克/小时TRH（16%）、40微克/小时TRH（38%）和200微克/小时TRH（42%）期间，观察到次最大组胺刺激的胃酸分泌量显著减少（与对照实验相比的减少百分比）。1000微克/小时的TRH没有显著影响。关于最大组胺刺激后的胃酸分泌量，500微克/小时的TRH没有显著影响。低血糖后，在40微克/小时TRH期间胃酸分泌量减少30%（p<0.05），在500微克/小时TRH期间减少37%（p<0.02）。在任何研究中，TRH对酸浓度均无影响。讨论了TRH可能与酸调节相互作用的潜在机制。
