Nakada K, Mitsuma T, Furusawa A, Maeda Y, Morise K
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
Gastroenterol Jpn. 1990 Aug;25(4):425-31. doi: 10.1007/BF02779330.
The effects of histamine and its related compounds on the concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) in the stomach, gastric juice and hypothalamus in rats were studied. Histamine, ranitidine or ethanolamine was injected intraperitoneally, and the rats were decapitated at various times after the injection. Ir-TRH concentrations in the stomach, gastric juice and hypothalamus were measured by a radioimmunoassay. Ir-TRH concentrations in the stomach decreased significantly after histamine injection and increased significantly after ranitidine injection in a dose-dependent manner, but did not change with ethanolamine. Ir-TRH concentrations in the gastric juice increased in a dose-dependent manner, peaking at 30 min after histamine injection, and its effect was blocked with ranitidine. Ir-TRH concentrations in the hypothalamus elevated significantly after histamine injection and reduced significantly after ranitidine injection, but did not change with ethanolamine. The effects of histamine on ir-TRH concentrations in the stomach and hypothalamus were significantly blocked with ranitidine, but not with ethanolamine. These findings suggest that histamine stimulates ir-TRH release from the stomach and inhibits ir-TRH release from the hypothalamus, and that these effects of histamine on ir-TRH release are mediated via an H2-receptor.
研究了组胺及其相关化合物对大鼠胃、胃液和下丘脑免疫反应性促甲状腺激素释放激素（ir-TRH）浓度的影响。腹腔注射组胺、雷尼替丁或乙醇胺，在注射后不同时间将大鼠断头。用放射免疫分析法测定胃、胃液和下丘脑中ir-TRH的浓度。组胺注射后胃中ir-TRH浓度显著降低，雷尼替丁注射后以剂量依赖方式显著升高，而乙醇胺注射后无变化。胃液中ir-TRH浓度呈剂量依赖性增加，在组胺注射后30分钟达到峰值，其作用被雷尼替丁阻断。组胺注射后下丘脑ir-TRH浓度显著升高，雷尼替丁注射后显著降低，乙醇胺注射后无变化。组胺对胃和下丘脑ir-TRH浓度的影响被雷尼替丁显著阻断，但未被乙醇胺阻断。这些发现表明，组胺刺激胃中ir-TRH释放并抑制下丘脑ir-TRH释放，且组胺对ir-TRH释放的这些作用是通过H2受体介导的。
