Fleischer I, Wainstein R, de Gibson A M
Acta Gastroenterol Latinoam. 1982;12(2):189-93.
Up to now, there has been no real evidence about the effectiveness of adjuvant surgical treatments in colo-rectal cancer in patients with no evidence of disease. Investigations are frequently out of the rules that must be followed to accept the effectiveness of some treatment. Results with radiotherapy as a loco-regional treatment and chemotherapy or immunotherapy as systemic treatments are contradictory. Our opinion is that, at least in patients with Dukes'C stage, efforts must persist to find the best adjuvant scheme to prolong the free-disease interval, or ideally, increasing the number of patients healed by surgery.
到目前为止,尚无确凿证据表明辅助手术治疗对无疾病证据的结直肠癌患者有效。研究往往不符合接受某种治疗有效性所必须遵循的规则。作为局部区域治疗的放疗以及作为全身治疗的化疗或免疫治疗的结果相互矛盾。我们认为,至少对于处于杜克C期的患者,必须继续努力寻找最佳的辅助治疗方案,以延长无病间隔期,或者理想情况下,增加通过手术治愈的患者数量。