Cagetti M, Casula G, Uccheddu A
Minerva Chir. 1979 Mar 15;34(5):335-44.
Large surgical series are agreed on the fact that the prognosis for radically operated colorectal cancer has improved little in the last twenty years. Reasons for these failures are, of course, local or remote recurrences. To improve the number of stable cures, experiments have been carried out with complementary or coadjuvant techniques whose purpose is to limit intra-operative dissemination of the tumour and to monitor the number of cancer cells that might remain after radical surgery. Such techniques have been applied at preoperative, intra-operative and post-operative phases. Results obtained so far have been uncertain but seem to point to the usefulness of intraoperative procedures in reducing the number of local recurrences and of postoperative chemotherapy with 5 FU which has improved five-year survival indices by 5-7%.
大型外科手术系列研究一致认为，在过去二十年中，接受根治性手术的结直肠癌患者的预后几乎没有改善。当然，这些治疗失败的原因是局部或远处复发。为了提高根治性治愈的数量，已经采用了辅助或协同辅助技术进行试验，其目的是限制肿瘤在术中的播散，并监测根治性手术后可能残留的癌细胞数量。这些技术已应用于术前、术中和术后阶段。到目前为止所获得的结果尚不确定，但似乎表明术中操作在减少局部复发数量方面是有用的，并且术后使用5-氟尿嘧啶化疗可使五年生存率提高5%-7%。
