Weidler B, von Bormann B, Seim M, Sturm G, Schwanen N, Hempelmann G
Anasth Intensivther Notfallmed. 1982 Dec;17(6):319-24.
A modification of neuroleptanalgesia by substituting fentanyl with buprenorphine is presented. Both anaesthesia techniques could be applied alternatively. We did not recognize any significant difference between the two groups concerning haemodynamics, the secretion of the so called stress hormones (antidiuretic hormone, cortisol) as well as the postoperative respiratory depression. The long lasting analgesia, which could be achieved by buprenorphine, can be advantageous in certain surgical interventions. The lack of a potent antagonist for buprenorphine in addition to its longer half-life for--not being of advantage in any anaesthesia--is discussed.
本文介绍了一种用丁丙诺啡替代芬太尼的神经安定镇痛法的改良方法。两种麻醉技术均可交替使用。我们未发现两组在血流动力学、所谓应激激素(抗利尿激素、皮质醇)的分泌以及术后呼吸抑制方面存在任何显著差异。丁丙诺啡可实现的长效镇痛在某些外科手术中可能具有优势。此外,还讨论了丁丙诺啡缺乏强效拮抗剂及其较长的半衰期——这在任何麻醉中都无优势。