Klose R, Ehrhart A, Jung R
Anasth Intensivther Notfallmed. 1982 Feb;17(1):29-34.
The degree of respiratory depression caused by buprenorphine and tramadol were studied in two groups of 25 patients each by means of Read's re-breathing technique. The estimations were made during the immediate postoperative stage in order to include potential residual effects of the general anaesthesia. The slope of the CO2 curve as a measure of respiratory depression decreased by 27 per cent after administration of 0.3 mg of buprenorphine, a reduction which equals that produced by potent morphine-type analgesics. The response to 50 mg of tramadol was a non-significant decrease by 3 per cent. At doses mentioned buprenorphine produced reliable pain relief, whereas with tramadol the failure rate was 28 per cent. There was no difference between the two drugs in respect of circulatory reactions and side-effects. Despite its depressing effect on the respiration (an action it shares with all potent analgesics) buprenorphine is a very useful analgesic because it provides excellent pain relief, has no or only minimal addictive properties and is not subject to the Dangerous Drugs Act.
采用里德再呼吸技术，在两组各25例患者中研究了丁丙诺啡和曲马多引起的呼吸抑制程度。评估在术后即刻进行，以便纳入全身麻醉的潜在残余效应。作为呼吸抑制指标的二氧化碳曲线斜率，在给予0.3毫克丁丙诺啡后下降了27%，这一下降幅度与强效吗啡类镇痛药产生的降幅相当。给予50毫克曲马多后的反应是无显著下降，降幅为3%。在上述剂量下，丁丙诺啡能可靠地缓解疼痛，而曲马多的失败率为28%。两种药物在循环反应和副作用方面无差异。尽管丁丙诺啡对呼吸有抑制作用（所有强效镇痛药都有此作用），但它是一种非常有用的镇痛药，因为它能提供极佳的疼痛缓解效果，无成瘾性或成瘾性极小，且不受《危险药物法》管制。
