血管加压素和血管紧张素对大鼠肝细胞中磷脂酰胆碱合成的抑制作用。
Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.
作者信息
Alemany S, Varela I, Mato J M
出版信息
Biochem J. 1982 Nov 15;208(2):453-7. doi: 10.1042/bj2080453.
Abstract
The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. The cationophore A23187 induced a similar inhibition of phosphatidylcholine synthesis. The addition of micromolar Ca2+ to rat liver microsomes inhibited the activity of CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. This inhibition is due a decrease in the Vmax. of the enzyme without affecting the Km for CDP-choline. It is concluded that Ca2+ regulates phosphatidylcholine synthesis in rat liver.
摘要
向分离的大鼠肝细胞中添加1微摩尔的血管加压素或血管紧张素会快速短暂抑制[甲基 - ³H]胆碱掺入磷脂酰胆碱的速率。离子载体A23187也会诱导类似的磷脂酰胆碱合成抑制。向大鼠肝脏微粒体中添加微摩尔浓度的钙离子会抑制CDP - 胆碱：1,2 - 二酰基甘油胆碱磷酸转移酶的活性。这种抑制是由于该酶的最大反应速度（Vmax）降低，而不影响其对CDP - 胆碱的米氏常数（Km）。得出的结论是钙离子调节大鼠肝脏中的磷脂酰胆碱合成。
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