Raghuram T C, Krishnaswamy K
Chemotherapy. 1982;28(6):428-33. doi: 10.1159/000238134.
Tetracycline pharmacokinetics were studied in a group of normal subjects and in patients with nutritional oedema. Though both groups of subjects received similar dose per kilogram body weight, plasma concentrations and area under the curve (AUC) were significantly higher in nutritional oedema patients. The total body clearance of the drug was reduced due to significant reductions in renal and non-renal clearance of drug. The volume of distribution (VB) was low, with significant increase in rate of transfer of drug from peripheral to central compartment (K21), indicating poor tissue sequestration of the drug in nutritional-oedema patients. In some respects, these alterations in kinetics of tetracycline in nutritional-oedema patients are different from our earlier observations made in undernourished subjects who had mild and moderate forms of malnutrition. These results suggest that changes in disposition of drugs are also influenced by the severity of malnutrition, and demand suitable alterations in dosage regimen.
在一组正常受试者和营养性水肿患者中研究了四环素的药代动力学。尽管两组受试者每公斤体重接受的剂量相似，但营养性水肿患者的血浆浓度和曲线下面积（AUC）显著更高。由于药物的肾清除率和非肾清除率显著降低，药物的全身清除率降低。分布容积（VB）较低，药物从外周室向中央室的转运速率（K21）显著增加，表明营养性水肿患者体内药物的组织隔离较差。在某些方面，营养性水肿患者四环素动力学的这些改变与我们早期对轻度和中度营养不良的营养不良受试者的观察结果不同。这些结果表明，药物处置的变化也受营养不良严重程度的影响，需要对给药方案进行适当调整。
