Sharma B, Mehta S, Nain C K, Mathur V S
Drug Nutr Interact. 1985;3(2):93-8.
An experimental model of protein energy malnutrition was produced in five young rhesus monkeys and the pharmacokinetics of antipyrine were studied at three points, initially, during protein energy malnutrition and following nutritional rehabilitation. In a separate group of animals, the estimation of hepatic enzyme aminopyrine N-demethylase was performed. There was a significant decrease in the elimination kinetics, the half life was increased, and the clearance rate was decreased in the malnourished animals, which correlated with a corresponding decrease in aminopyrine N-demethylase activity.
在五只幼年恒河猴中建立了蛋白质能量营养不良的实验模型，并在三个时间点研究了安替比林的药代动力学，即最初、蛋白质能量营养不良期间以及营养康复后。在另一组动物中，对肝酶氨基比林N-脱甲基酶进行了测定。营养不良的动物消除动力学显著降低，半衰期延长，清除率降低，这与氨基比林N-脱甲基酶活性相应降低相关。
