醛糖还原酶抑制对糖尿病大鼠运动神经传导速度的影响。
The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.
作者信息
Yue D K, Hanwell M A, Satchell P M, Turtle J R
出版信息
Diabetes. 1982 Sep;31(9):789-94. doi: 10.2337/diab.31.9.789.
PMID:6819173
Abstract
This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.
摘要
本研究检测了一种醛糖还原酶抑制剂（CP 45634，索比尼尔，辉瑞公司，纽约）对链脲佐菌素诱导的糖尿病大鼠神经病变的影响。对病程为2至9个月的糖尿病大鼠进行4周的索比尼尔治疗，可降低坐骨神经山梨醇浓度，并改善运动神经传导速度。索比尼尔是否能预防慢性糖尿病神经病变仍有待确定。
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