Thabrew M I, Emerole G O, Olorunsogo O O
Res Commun Chem Pathol Pharmacol. 1982 Dec;38(3):481-95.
In both protein-energy malnourished (PEM) and normal rats, chloramphenicol (7.5 mg/kg) competitively inhibits the activities of aniline hydroxylase and p-aminopyrine N-demethylase. The decrease in enzyme activities was very much less in PEM rats. In both groups of animals, chloramphenicol also lowered the respiratory control ratio (RCR) of mitochondria. However, as with the microsomal function, the decrease in mitochondrial RCR in PEM rats (18.2%) was much less than that (45.8%) in normal rats. These results suggest that the toxic effects of chloramphenicol could be less in PEM conditions.
在蛋白质 - 能量营养不良（PEM）大鼠和正常大鼠中，氯霉素（7.5毫克/千克）竞争性抑制苯胺羟化酶和对氨基苯丙胺N - 脱甲基酶的活性。PEM大鼠中酶活性的降低要少得多。在两组动物中，氯霉素还降低了线粒体的呼吸控制率（RCR）。然而，与微粒体功能一样，PEM大鼠线粒体RCR的降低（18.2%）远低于正常大鼠（45.8%）。这些结果表明，在PEM情况下氯霉素的毒性作用可能较小。
