Meyer-Rienecker H J, Wegener S, Hitzschke B, Richter K V
Acta Neurol Scand. 1982 Dec;66(6):709-12. doi: 10.1111/j.1600-0404.1982.tb04537.x.
The HLA typing of 100 patients with multiple sclerosis (MS) and their differentiation according to the dynamics of the disease, the type of course and the degree of defect showed the following results: a significant increase in frequency of HLA B7 (P less than 0.05), independent of the severity of illness, a 4-fold increased frequency of the HLA haplotype A25, B18 with augmented occurrence in slight to moderate severity of the disability degree (P less than 0.05), less so in the dynamics of the disease, and only partially so in the relapsing-remittent course. These HLA constellations provide only a hint at the prognosis of MS; the findings could be an expression of the heterogeneity of the disease.
对100例多发性硬化症（MS）患者进行HLA分型，并根据疾病动态、病程类型和缺陷程度进行区分，结果如下：HLA B7频率显著增加（P<0.05），与疾病严重程度无关；HLA单倍型A25、B18频率增加4倍，在轻度至中度残疾程度时出现频率增加（P<0.05），在疾病动态方面增加较少，在复发缓解型病程中仅部分增加。这些HLA组合仅为MS的预后提供了一个线索；这些发现可能是疾病异质性的一种表现。
