Wetsel W C, Rogers A E, Newberne P M
Cancer Detect Prev. 1981;4(1-4):535-43.
While there is no convincing direct evidence of an influence of specific dietary factors on breast cancer in women, the overall geographic correlation between risk of breast cancer and food consumption patterns suggests a positive link. Epidemiologic studies have correlated breast cancer rates with fat consumption. Increased dietary fat, through intestinal microflora production of estrogens, might expose breast tissue to chronic, excessive stimulation and increase cancer risk. Laboratory animal studies have shown that dietary fat affects response to DMBA carcinogenesis. Studies in our own laboratory have shown that 20% corn oil or lard increased DMBA mammary tumorigenesis, compared to rats fed 5% fat; 20% corn oil accelerated sexual maturation, but 20% lard did not. The mechanisms of tumorigenesis under such circumstances are unknown.
虽然没有令人信服的直接证据表明特定饮食因素会对女性乳腺癌产生影响，但乳腺癌风险与食物消费模式之间的整体地理相关性表明存在正相关联系。流行病学研究已将乳腺癌发病率与脂肪摄入量关联起来。通过肠道微生物群产生雌激素，饮食中脂肪增加可能会使乳腺组织受到慢性、过度刺激并增加癌症风险。实验动物研究表明，饮食脂肪会影响对二甲基苯并蒽（DMBA）致癌作用的反应。我们自己实验室的研究表明，与喂食5%脂肪的大鼠相比，20%玉米油或猪油会增加DMBA诱导的乳腺肿瘤发生；20%玉米油会加速性成熟，但20%猪油则不会。在这种情况下肿瘤发生的机制尚不清楚。
