Hajjar J J, Schwartz R G, Mirkin K R, Tomicic T K
Digestion. 1982;25(4):236-43. doi: 10.1159/000198838.
Leucine absorption across the mechanically obstructed rat intestine was studied by in vivo and in vitro techniques. It varied between the early (after 2 h) and late (after 18 h) phases of the obstruction. During the early phase there was a reduction in mucosal uptake and in net absorption of the amino acid. At 18 h the inhibition in mucosal uptake was more prominent both above and below the occlusion site but net absorption was only reduced below the obstruction and was relatively unaffected above it. Mannitol and nonmediated leucine absorption were also increased above the obstruction. The findings during the late phase suggest the presence of an increase in leucine permeability across the intestine above the occlusion site. The observed normal rate of net leucine absorption across this segment is thought to be due to enhancement in intestinal diffusion which could be masking the depression in mucosal uptake.
通过体内和体外技术研究了亮氨酸在机械性梗阻大鼠肠道中的吸收情况。在梗阻的早期（2小时后）和晚期（18小时后）阶段，其情况有所不同。在早期阶段，氨基酸的黏膜摄取和净吸收均减少。在18小时时，梗阻部位上下的黏膜摄取抑制更为明显，但净吸收仅在梗阻部位以下减少，而在其上方相对未受影响。梗阻部位上方的甘露醇和非介导的亮氨酸吸收也增加。晚期阶段的研究结果表明，梗阻部位上方的肠道亮氨酸通透性增加。据认为，该节段亮氨酸净吸收的正常速率是由于肠道扩散增强，这可能掩盖了黏膜摄取的降低。
